성연선 사진

성연선 | 의과대학 의예과

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소개

1991년 서울대학교 의과대학을 졸업하고 동 대학원에서 석사(1993) 박사
(1997)학위를 취득 하였다. 대학원과정에서 퓨린염기 이화대사 효소인
guanine deaminase를 정제하고 클로닝하였으며 신경생화학연구로서 세포의
증식과 분열에 중요한 역할을 하는 단백질 인산화 효소인MAPkinase의 신호
전달에 관하여 연구하였다. 1990년대 말부터 세포분열과정 의 세포골격단백질
인 CKAP2에 관하여 연구를 시작하였고 이를 계기로 세포주기와 세포분열연구
를 위하여 미국으로 연구를 나갔고 미국 국립암센타에서 세포분열및 세포분
열 check point 조절에 중요한 역할을 하는 polo kinase와 cdk에 대한 연구를
주로 하였으며 cdk 의 선택적 억제를 통한 암세포치료에 대하여 연구하였다.
2009년부터 2013년까지 세계수준의 연구중심대학 사업 (대학원 나노바이오의과학과)에 참여하였고 현재는 다시 의과대학 의예과에 복귀하였다.
현재는 주로 세포의 성장및 생존의 제어에 관여하는 인산화 신호전달 경로 그리고 이와 관련된 유전체, 단백질체의 변화에 대하여 연구하고 있다.

학력

  • [1991] 학사 서울대학교 의학
  • [1993] 석사 서울대학교 의학 생화학
  • [1997] 박사 서울대학교 의학 생화학

주요연구분야

guanine deaminase의 뇌조직에서의 역할
영양학, 아미노산 대사
암발생, 세포사멸, 노화 그리고 세포주기 조절
세포주기 체크포인트
항암제 내성의 단백질 인산화 신호전달 경로
세포사멸 기능억제 암세포에서의 세포사멸에 관련된 신호전달 경로
유전체 발현 분석

컨설팅 가능 분야

의학생화학, 임상영양학, 인체 대사학
암세포생물학, 세포주기 및 세포분열
생체세포 영상기술(confocal microscope, live cell imaging)및 응용
세포주기 분석및 응용
유전물질 전달체로서의 아데노 바이러스, 렌티바이러스
유전체 발현 분석

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