심호섭 사진

심호섭 | 의과대학 의예과

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소개

1996년 University of California at Davis에서 "원시생식세포 유래 다능성 줄기세포주의 수립"으로 생리학박사학위를 취득하고 1999년까지 동 대학 Embryo Transfer Laboratory에서 박사후 연구원으로 활동하였다. 1999년부터 2000년까지 차의과학대학교 의학과 생리학교실 조교수, 2001년부터 단국대학교 의과대학 생리학교실 주임교수로 재직하던 중 2009년 교육과학기술부의 세계수준의 연구중심대학 (WCU; World Class University) 사업에 따라 개설된 나노바이오의과학과에 참여하여 세포재프로그래밍연구실에서 복제, 줄기세포 및 형질전환 관련 연구를 진행하고 있다. 강의로는 인체생리학, 내분비학, 발생학, 줄기세포생물학 등을 담당하고있다. 현재 미래창조과학부 및 보건복지부의 바이오이종장기사업단에서 이종이식을 위한 형질전환 복제동물의 생산 및 체세포의 역분화에 관한 연구를 진행하고 있다.

학력

  • [1985] 학사 건국대학교 축산학
  • [1987] 석사 건국대학교 축산학 가축번식학
  • [1996] 박사 Univ. of California at Davis 생리학 생리학

주요연구분야

배아줄기세포의 수립 및 분화
형질전환동물 생산

컨설팅 가능 분야

발생공학, 유전자이식, 세포치료

연구업적

  • 연구보고서[20070424] 돼지 생식선줄기세포를 이용한 이종간 장기이식 모델의 개발
  • 연구보고서[20060713] 배아줄기세포를 이용한 낭포성섬유증 질환모델 돼지의 개발
  • 일반논문[20160901] Biomaterials control of pluripotent stem cell fate for regenerative therapy
  • 일반논문[20160801] Complete reduction of p53 expression by RNA interference following heterozygous knockout in porcine fibroblasts
  • 일반논문[20160301] Treatment of Exogenous GDF9 and BMP15 during In Vitro Maturation of Oocytes increases the Cell Number of Blastocysts in Pigs
  • 일반논문[20160301] Nuclear Transfer using Human CD59 and IL-18BP Double TransgenicFetal Fibroblasts in Miniature Pigs
  • 일반논문[20150201] Methylation and expression changes in imprinted genes H19 and Igf2 during serial somatic cell nuclear transfer using piglet fibroblasts
  • 일반논문[20150131] Comparative N-linked blycan analysis of wild-type and alpha 1,3-galactosyltransferase gene knock-out pig fibroblasts using mass spectrometry approaches
  • 일반논문[20141003] Targeted disruption of Ataxia-telangiectasia mutated gene in miniature pigs by somatic cell nuclear transfer
  • 일반논문[20120814] α1,3-galactosyltransferase deficiency in germ-free miniature pigs increases N-glycolylneuraminic acids as the xenoantigenic determinant in pig-human xenotransplantation
  • 일반논문[20120810] Inheritance of mitochondrial DNA in serially recloned pigs by somatic cell nuclear transfer (SCNT)
  • 일반논문[20120730] Hypomethylation of DNA in Nuclear Transfer Embryos from Porcine Embryonic Germ Cells
  • 일반논문[20120201] In vitro development of nuclear transfer embryos derived from porcine embryonic germ cells and their descendent neural precursor cells
  • 일반논문[20110401] Comparison of potency between histone deacetylase inhibitors trichostatin A and valproic acid on enhancing in vitro development of porcine somatic cell nuclear transfer embryos
  • 일반논문[20110315] Resurrection of an alpha-1,3-galactosyltransferase gene-targeted miniature pig by recloning using postmortem ear skin fibroblasts
  • 일반논문[20110201] Development of Complete Thoracic Spinal Cord Transection Model in Rats for Delayed Transplantation of Stem Cells
  • 일반논문[20101001] Production of human CD59-transgenic pigs by embryonic germ cell nuclear transfer
  • 일반논문[20090930] Factors Affecting Primary Culture of Nuclear Transfer Blastocysts for Isolation of Embryonic Stem Cells in Miniature Pigs
  • 일반논문[20090501] Cytolytic assessment of hyperacute rejection and production of nuclear transfer embryos using hCD46-transgenic porcine embryonic germ cells
  • 일반논문[20090201] Production of bovine nuclear transfer embryos using fibroblasts transfected with single-chain human follicle-stimulating hormone gene
  • 일반논문[20081101] Isolation of embryonic stem cells from enhanced green fluorescent protein-transgenic mouse and their survival in the cochlea after allotransplantation
  • 일반논문[20080630] Enhanced green fluorescent protein gene under the regulation of human Oct4 promoter as a marker to identify reprogramming of human fibroblasts
  • 일반논문[20080531] Derivation of embryonic germ cells from post migratory primordial germ cells, and methylation analysis of their imprinted genes by bisulfite genomic sequencing
  • 일반논문[20080401] Gene targeting in mouse embryos mediated by RecA and modified single-stranded oligonucleotides
  • 일반논문[20080301] Effects of sperm membrane disruption and electrical activation of oocytes on in vitro development and transgenesis of porcine embryos produced by intracytoplasmic sperm injection
  • 일반논문[20071201] Transgenesis and nuclear transfer using porcine embryonic germ cells
  • 일반논문[20070630] Comparison of in vitro development of porcine embryos derived from transfer of embryonic germ cell nuclei into oocytes by electrofusion and piezo-driven microinjection
  • 일반논문[20061001] Tetracycline-inducible gene expression in nuclear transfer embryos derived from porcine fetal fibroblasts transformed with retrovirus vectors
  • 일반논문[20050118] Increased caveolin-1, a cause for the declined adipogenic potential of senescent human mesenchymal stem cells
  • 일반논문[20041231] Polscope-assisted enucleation for nuclear transfer in mice
  • 일반논문[20040723] Development of transgenic chickens expressing enhanced green fluorescent protein
  • 일반논문[20040528] Use of somatic cell nuclear transfer technology to produce human follicle-stimulating hormone (hFSH) transgenic cows
  • 일반논문[20040501] Attempts to enhance production of porcine chimeras from embryonic germ cells and preimplantation embryos
  • 일반논문[20020901] Growth, development and gene expression by in vivo- and in vitro-produced day 7 and 16 bovine embryos
  • 일반논문[20020901] Improved development of ICR mouse 2-cell embryos by the addition of amino acids to a serum-, phosphate- and glucose-free medium
  • 일반논문[20020711] Embryonic stem cells: From knockout mice to cell replacement therapy
  • 일반논문[20020301] Nuclear and microtubule reorganization in nuclear-transferred bovine embryos
  • 일반논문[20000901] In vitro development of porcine enucleated oocytes reconstructed by porcine fetal fibroblasts and cumulus cells
  • 일반논문[20000901] In vitro development of green fluorescent protein (GFP) transgenic bovine embryos after nuclear transfer using different cell cycles and passages of fetal fibroblasts
  • 일반논문[20000601] Intracytoplasmic sperm injection in pigs
  • 일반논문[19990301] Lack of stage-specific embryonic antigen-1 expression by bovine embryos and primordial germ cells
  • 일반논문[19980201] In vitro survival and proliferation of porcine primordial germ cells
  • 일반논문[19971101] Isolation of pluripotent stem cells from cultured porcine primordial germ cells
  • 지식재산권[20120827] 알파 1,3-갈락토실트랜스퍼라아제 유전자 타겟팅 벡터 (Alpha 1,3-galactosyltransferase gene targeting vector)
  • 지식재산권[20120517] 이종 장기 이식용 미니 복제돼지 생산을 위한 유전자 조작된 세포주 및 그의 생산방법 (Genetically-modified cell line for producing cloned miniature pigs for xenotransplantation and method for preparing the same)
  • 지식재산권[20110922] 알파 1,3-갈락토실트랜스퍼라아제 유전자 타겟팅 벡터 및그의 용도 (Alpha 1,3-galactosyltransferase gene targeting vector and uses thereof)
  • 지식재산권[20110705] 알파 1,3-갈락토실트랜스퍼라아제 유전자의 위치에 DAF 유전자를 넉인한 체세포 제조 방법 (Methods for production of knock-in somatic cells of DAF gene in alpha 1,3-galactosyltransferase gene locus)
  • 지식재산권[20080415] 설치류의 완전척수손상모델의 제조방법 및 그완전척수손상모델
  • 지식재산권[20060530] 재조합 hFSH 유전자 및 이를 내장하는 발현용 벡터
  • 지식재산권[20030408] Embryonic germ cells, method for making same, and using the cells to produce a chimeric porcine
  • 지식재산권[19970701] Ungulate embryonic stem-like cells, making and using the cells to produce a transgenic ungulate
  • 지식재산권[19970701] Ungulate embryonic stem-like cells, method for making and using the cells to produce transgenic ungulates
  • 학술발표[20150516] Blastocyst Complementation: Towards Compensation of Organogenesis Using Pluripotent Stem Cells
  • 학술발표[20130121] Rapid production of α-1.3-galactosyltransferase-deficient miniature pigs by nuclear transfer following neonatal skin biopsy and loss of heterozygosity
  • 학술발표[20130121] Effect of exogenous Oct4 protein on direct conversion of human fibroblasts into neural stem cells
  • 학술발표[20120109] Targeted disruption of ataxia-telangiectasia mutated gene in miniature pigs by somatic cell nuclear transfer
  • 학술발표[20091119] Genetically modified clone pigs for pig-to-human xenotransplantation
  • 학술발표[20091023] Genetically modified clone pigs for xenotransplantation
  • 학술발표[20090710] Effects of glass-derived ions on human dental pulp stem cells
  • 학술발표[20081113] Porcine embryonic germ cells: Isolation, differentiation and nuclear transfer for xenotransplantation research
  • 학술발표[20081024] Purity evaluation of FACS-sorted boar sperm using quantitative real-time PCR
  • 학술발표[20080105] In vitro development of nuclear transfer embryos derived from porcine embryonic germ cells and their descendent neural precursor cells
  • 학술발표[20080105] Establishment of embryonic stem cell lines derived from EGFP-transgenic mouse and their survival in the cochlea of C57BL/6 mice
  • 학술발표[20070815] Embryonic germ cell nuclear transfer to produce human CD59 transgenic pigs
  • 학술발표[20070622] Use of porcine embryonic germ cells for xenotransplantation research
  • 학술발표[20070622] In vitro development of nuclear transfer embryos from porcine embryonic germ cells post and prior to their neural differentiation
  • 학술발표[20070106] Hypomethylation of DNA in nuclear transfer embryos from porcine embryonic germ cells
  • 학술발표[20061027] Production of cloned piglets from human CD59-transgenic embryonic germ cells for reduction of hyperacute rejection in pig-to-human xenotransplantation
  • 학술발표[20061017] Reestablishment of complete transection model of rat spinal cord and the effect of labeled human embryonic stem cell transplantation
  • 학술발표[20060108] Production of nuclear transfer embryos from porcine fetal fibroblast cells carrying a tetracyclin-inducible transgene
  • 학술발표[20060108] Cytolytic analysis and nuclear transfer of hCD46-transgenic porcine embryonic germ cells to develop an in vitro model of xenotransplantation
  • 학술발표[20051028] Production of hCD46-transgenic clone embryos using embryonic germ cell nuclear transfer in pigs
  • 학술발표[20051028] Hypomethylation of DNA in embryos from stem cell nuclear transfer in pigs
  • 학술발표[20050617] Production of cloned embryos using porcine fetal fibroblast cells with tetracycline-inducible expression of transgene
  • 학술발표[20050617] Transgenenesis, sytolytic analysis and nuclear transfer of porcine embryonic germ cells to develop in vitro model of xenotransplantation
  • 학술발표[20050111] Establishment of mouse pluripotent stem cells generated from primordial germ cells
  • 학술발표[20050111] Modified single-stranded oligonucleotide-recombinase complex mediates gene targeting in mouse embryos
  • 학술발표[20050111] Transgenesis and nuclear transfer using stem cells from cultured porcine primordial germ cells
  • 학술발표[20041211] Isolation, transgenesis and nuclear transfer of undifferentiated stem cells from cultured porcine primordial germ cells
  • 학술발표[20041005] Use of somatic cell nuclear transfer technology in livestock
  • 학술발표[20040624] Transgenesis and nuclear transfer using porcine embryonic germ cells
  • 학술발표[20040624] Gene targeting in mouse embryos mediated by recA and modified single-stranded oligonucleotides
  • 학술발표[20040624] Establishment of mouse pluripotent stem cells generated from primordial germ cells
  • 학술발표[20031009] Cloning in Livestock and Its Applications
  • 학술발표[20030811] Production of bovine nuclear transfer embryos using fibroblasts transfected with single-chain human follicle-stimulating hormone gene
  • 학술발표[20021101] Expression of recombinant human follicle-stimulating hormone in the Chinese hamster ovary cell
  • 학술발표[20020828] Somatic Cell Nuclear Transfer in Domestic Animals
  • 학술발표[20020713] Embryonic Stem Cells: From Knockout Mice to Cell Replacement Therapy
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